Future alternative therapies for β-thalassemia

Pathophysiology of β Thalassemia— A Guide to Molecular Therapies

The central mechanism underlying the pathophysiology of the β thalassemias can be related to the deleterious effects of imbalanced globin chain synthesis on erythroid maturation and survival. An imbalance of the α/non-α globin chains leads to an excess of unmatched α globin which precipitates out, damaging membrane structures leading to accelerated apoptosis and premature destruction of the ery...

Psychological Therapies: The Missing Link in Improving Treatment Adherence in Patients with β-thalassemia Major

Gene Therapy for β - Thalassemia

Gene transfer for β-thalassemia requires gene transfer into hematopoietic stem cells using integrating vectors that direct regulated expression of β globin at therapeutic levels. Among integrating vectors, oncoretroviral vectors carrying the human βglobin gene and portions of the locus control region (LCR) have suffered from problems of vector instability, low titers and variable expression. In...

Alternative Therapies for Cellulitis

Key Points: • Conventional treatment of cellulitis includes administration of IV antimicrobials, nonsteroidal anti-inflammatory drugs, and cold hosing and bandaging the limb. • Survival rates of 55-89% have been reported, but even horses that do recover can experience continued lameness or recurrence of infection. • Adjunctive therapies aimed at achieving higher antibiotic concentrations at the...

Alternative therapies.

Authors Kamran Amwar, Nicholas S.Y. Jim, Kath Huckbody and Ian Hughes Distributor pharma-CAL-ogy, British Pharmacological Society, 16 Angel Gate, City Road, London, EC1V 2SG. United Kingdom. Tel: 44-(0)207417-0382. Fax: 44-(0)20-7417-0114. E-mail: [email protected]. Software type Macromedia Authorware Subject area Alternative Therapies/Clinical trials Intended audience 16 plus -Undergraduate Cost £...